Madison County
- Alton, Alton Amtrak Station (HIBS MS-2014-1)
- Alton, Alton Bridge, spanning Mississippi River between Illinois & Missouri (HAER IL-21)
- Alton, Alton Mental Health Center (Cover Document) (HIBS MS-1999-1)
- Alton, Alton Mental Health Center, Linden Building (HIBS MS-1999-1A)
- Alton, Alton National Cemetery, 600 Pearl Street (HALS IL-1)
- Alton, Alton National Cemetery, Rostrum, 600 Pearl Street (HALS IL-1-A)
- Alton, Cut Stone Culvert, Milepost 254.30 (HIER MS-2014-2)
- Alton, Koenig House, 829 East 4th Street (covenant, EXPIRED)
- Alton, Shurtleff College, Loomis Hall (HABS IL-25-20)
- Alton, Upper Mississippi River 9-Foot Channel Project, Lock & Dam 26 (HAER IL-31)
- Alton vicinity, Upper Mississippi River 9-Foot Channel Project, Lock & Dam 26R (HAER IL-32)
- Bethalto, Village Hall, 124 Main Street (covenant, EXPIRED)
- Collinsville, Brooks Catsup Bottle, Highway 159 (HABS IL-1230)
- Collinsville, Commercial Streetscape (HABS IL-1231)
- East Alton, Olin Corporation Magazine Area Bridge (HIER MS-1991-1)
- Edwardsville, Benjamin Stevenson House, 409 South Buchanan (covenant, EXPIRED)
- Edwardsville, Berleman House, 115 South Main (covenant, EXPIRED)
- Edwardsville, Chain of Rocks Road Bridge (HIER MS-2007-1)
- Edwardsville, Gaius Paddock Farm, Springfield Road (HABS IL-237)
- Edwardsville, Hooper Warren Print Shop (HABS IL-238)
- Edwardsville, Old Wabash Hotel, Main & Union Streets (HABS IL-236)
- Godfrey, Godfrey Congregational Church, State Route 111 (HABS IL-25-10)
- Godfrey, Godfrey Homestead, Delhi Road (HABS IL-25-9)
- Granite City, United States Army St. Louis Area Support Center (HAER IL-17)
- Granite City, Upper Mississippi River 9-Foot Channel Project, Lock & Dam 27 (HAER IL-33)
- Mitchell, Lenox Interlocking Tower (HIER MS-2018-1)
- North Alton, North Alton Confederate Cemetery, 635 Rozier Street (HALS IL-6)
- Rural Madison County, Archaeological sites 11MS2208 and 11MS2210 (covenant)